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Drug Delivery Systems

Mykito Chitosan is the world’s purest Non-Animal chitosan. This chitosan free from beta-glucans, heavy metals, and other common contaminants typically found in conventional chitosan. The Mykito technology is highly robust, consistently repeatable, and delivers consistent results.

Orthopedic implants

Chitosan serves as an effective drug delivery system, enhancing drug performance while adding biocompatibility when integrated into orthopedic implants. Using dip-coating techniques, chitosan layers can encapsulate drugs such as antibiotics, enabling controlled release into the post-operative wound environment. This approach helps target common pathogens, supports bone healing, prevents infections, and reduces inflammation [Soares].

X-ray image showing a knee joint with a visible metal prosthesis from a total knee replacement surgery
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Dental implants

Chitosan’s mucoadhesive nature and ability to enhance penetration make it an excellent candidate for drug delivery systems. In dental implants, chitosan can be used to incorporate bone morphogenetic proteins and other growth factors, supporting and accelerating bone formation during the peri-operative period. [Aguilar].

Cardiac implants

The physical and chemical properties of Chitosan make it an ideal carrier for biomolecules in cardiac repair and regeneration. Its positive charge and hydrophilic nature create a favorable microenvironment, enabling effective delivery and synergistic interaction with biomolecules.

[Patel].

Medical illustration of a chitosan-coated catheter inserted through a blood vessel and positioned at the aortic valve of the human heart, with the aortic valve labeled.
A close-up of a yellow and white capsule pill with small white and yellow beads inside

Drug delivery vector

Chitosan nanoparticles are highly effective for encapsulating and delivering drugs in forms such as microparticles, nanoparticles, and hydrogels. They can be utilized in both standard and specialized therapies across multiple body systems. Chitosan can be engineered to enable sustained, controlled, and site-specific drug release [Garg,Su], making it suitable for targeted delivery to tissues including ocular, oral, nasal, and genitourinary systems.

Gastrointestinal/Oral Drug Delivery

A major challenge in drug development is achieving sufficient gastrointestinal absorption. Chitosan can be used as a coating or binding material for tablets, capsules, and granules to protect drugs from the harsh gut environment. Through targeted physical and chemical modifications, chitosan can be tailored to resist degradation by low gastric pH, enzymes, and mucus, ensuring effective delivery to the intended sites. [Pathomthongtaweechai].

A chalk drawing of the human digestive system is shown on a blackboard, highlighting the stomach, small intestine, and large intestine within a torso outline
A woman uses a nasal spray outdoors, holding the bottle to one nostril with a blurred green background.

Nasal Drug Delivery

Chitosan can be employed in nasal drug delivery to overcome rapid mucociliary clearance. When administered as micro- or nanoparticles, its mucoadhesive properties enable prolonged drug absorption and sustained therapeutic action. Studies have demonstrated its effectiveness in providing lasting relief for conditions such as rhinitis and COVID-19. [Wang,Pyrc].

Drug Delivery

Chitosan-based hydrogels serve as highly effective drug delivery systems. Acting as high-capacity reservoirs with strong adhesion to local tissues, they enable sustained drug release, helping to optimize the biochemical and physiological environment for healing. [Freedman].

An open tin of white cream is displayed against a bright yellow background.
A golden retriever lies on a metal table at a veterinary clinic while a person in scrubs gently holds it.

Drug Delivery

Chitosan-based micro- and nano-carriers can also be used in veterinary applications to enable safe, effective, and targeted delivery of medications. They are suitable for administering enteral and mucosal drugs or vaccines, ensuring that the active agents reach the intended site for stable absorption. Their effectiveness relies on chitosan’s structural integrity for chemical and mechanical protection, mucoadhesive properties for prolonged absorption, and immunomodulatory effects to enhance the therapeutic response.

[Senel,Drewnowska,Maldonado-Cabrera].

Nanoparticle Formulations

Chitosan can be formulated into nanoparticles to compact and deliver genetic material, such as DNA plasmids and RNA, for gene therapy. Since genetic materials are easily degraded in bodily tissues, effective transfection vectors are essential for successful delivery. Chitosan nanoparticles provide safe transport of various genetic materials into cells, with their positively charged surfaces enhancing cellular permeability and improving uptake and transfection efficiency. [Bowman].

Two yellow capsules floating inside a transparent bubble, surrounded by a blue, glowing, abstract background.

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