Gastrointestinal Drug Delivery
Mykito Chitosan is the purest Non-Animal chitosan in the world. This chitosan does not have the betaglucins, heavy metals and other contaminants that are commonly found in chitosan. The Mykito technology is robust, repeatable and produces consistent results.
Drug Delivery Systems
Chitosan nanoparticles can also effectively encapsulate and deliver drugs in the form of microparticles, nanoparticles, and hydrogels. This can be incorporated into the delivery of common and specialized treatments across various body systems. Chitosan can be customized to provide sustained, controlled, and site-specific release of drugs [Garg,Su]. This can be applied across various bodily tissues, including the delivery to ocular, oral, nasal and genitourinary systems.
Gastrointestinal/Oral Drug Delivery
One of the main challenges in drug development is ensuring adequate gastrointestinal absorption, and Chitosan can be utilized as a coating or binding material for tablets, capsules, and granules to overcome the hazardous environment of the gut. Through various physical and chemical modifications to Chitosan, this can tailor its protection against degradation by low gastric pH, enzymes, and mucus, ensuring sufficient delivery to its intended sites [Pathomthongtaweechai].
Mucoadhesive Properties
The physical properties of Chitosan as a delivery device also address commonly encountered mucoadhesive issues. It can adhere to various surfaces, including dry epithelial and moist mucosal tissues, meaning that it improves the steady release and availability of drugs across any tissue [Garg]. It also forms films to further stabilize the drug reservoirs and ensures effective delivery [Campisi,Senel].
Controlled Release
The drug release profile of Chitosan nanocapsules and nanospheres can also be tailored by changing its structures. These release systems most commonly achieve a bi-phasic pattern to reduce frequent dosing, with rapid initial release followed by a stable and sustained release [Heriana].
Weight-loss Adjuvant
The addition of Chitosan to the diet as a supplement or adjuvant may also have weight-reduction effects through binding to fats and preventing their absorption. This was observed in animal studies, with some studies also showing weight improvements for obese participants compared to placebo alone. However, the quality of evidence remains debated and further research is needed to quantify its effects [Bull].
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