Dental Applications
Mykito Chitosan is the purest Non-Animal chitosan in the world. This chitosan does not have the betaglucins, heavy metals and other contaminants that are commonly found in chitosan. The Mykito technology is robust, repeatable and produces consistent results.
Surface Modification
The surface of dental implants may be modified using Chitosan to increase the rate of healing and osseointegration [Alnufaiy]. The surface modification can be achieved by laser-treating the implant before coating it with Chitosan. This promotes biomineralization and osteoblast formation by providing biocomposite scaffolds.
Drug Delivery
Chitosan’s mucoadhesive and enhanced penetration properties make Chitosan a suitable drug delivery system. Dental implants with Chitosan may be used to incorporate bone morphogenetic proteins and various growth factors to induce and promote bone formation peri-operatively [Aguilar].
Antimicrobial Properties
The natural antimicrobial activity of Chitosan, arising from its cationic and polymerization properties, can also benefit dental implants. It is effective against a variety of pathogens, including bacteria, fungi, yeast, and algae [Savard,Choi]. This reduction of bacteria will assist with peri-implantation healing [Camacho-Alonso].
Bone preservation
Bone loss, inflammation, and peri-implantitis present significant challenges in dental implantation. The use of Chitosan brushes provides more effective bacteriostatic effects than the standard titanium curette treatment and shown to improve inflammation and maintain stable bone levels [Zera,Wohlfahrt,Wohlfahrt].
Anti-Inflammation
Tissue inflammation poses a significant concern to healing and bone loss in dental implants. Implants with embedded Chitosan can remain inert and are both non-antigenic and carry anti-inflammatory properties [Lopez-Valverde]
Bone Regeneration
Chitosan can also make effective scaffolds, as they can promote bone regeneration [Levengood]. They can offer support for the attachment and proliferation of osteoblasts and encourage bone matrix formation. This can be applied to dental implants to assist dental pulp regeneration as well [Moreira].
Cement enhancement
Apart from its antibacterial effects on implants, Chitosan can be added to standard glass ionomer cement and similar composites to both improve its compressive and flexure strengths for better bonding and integrity [Mishra].
Hemostasis
Chitosan dressings can be useful peri-operatively as they induce platelet adhesion, aggregation, and blood coagulation. As it electrostatically interacts with proteins in the blood, this helps enhance bleeding control and clotting at wound sites and assists with the healing process [Keast].
Wound healing
Oral wounds can also benefit from the addition of Chitosan in standard antiseptic compounds. Topical gels infused with Chitosan are more effective antimicrobials and lead to improved rate and quality of wound healing [Madrazo-Jimenez,Kilic].
Antimicrobial and Erosion prevention
Chitosan can also augment traditional fluoride-based toothpaste to further prevent erosions. Its chemical properties and high pH levels help it adhere to dental surfaces and counter the erosive effects of acids [Schulueter,Mohire,Carvalho].
Biofilm protection
Chitosan can also be combined with mouthwash and floss to harness its antibacterial properties in protecting the tooth surface from biofilm formation. The addition of Chitosan to fluoride and chlorhexidine produces synergistic effects to minimize biofilm, plaque, and gingival irritation [Rahayu,Pandiyan].
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