Regenerative Medicine
Mykito Chitosan is the purest Non-Animal chitosan in the world. This chitosan does not have the betaglucins, heavy metals and other contaminants that are commonly found in chitosan. The Mykito technology is robust, repeatable and produces consistent results.
Tissue engineering
Chitosan can be used to create cardiac extracellular matrix scaffolds to repair congenital defects [Lv]. These implants can integrate well into the body tissue and the porous scaffold structure effectively facilitates cell survival and proliferation. Chitosan implants can also improve recovery by limiting scarring and promoting blood vessel development following heart attacks [Wang]. Valves can also be coated in Chitosan to enhance their regenerative potential [Jahnavi].
Stem cell and gene therapy
After traumatic events such as heart attacks, the heart can be significantly impaired and can potentially be addressed with Chitosan. Chitosan-based scaffolds and nanofibers can provide an effective platform for cardiac stem cells, or injected stem cells, to grow and spread [Patel]. Stem cells are cells that can differentiate into other types of cells, such as heart cells. By delivering stem cells to the heart, it is possible to repair damaged heart tissue. Chitosan nanofibers and scaffolds can also stimulate the genes involved in cardiac contraction and coupling to facilitate electrical conduction [Martins].
Transplant Applications
The effects of Chitosan also extend to the modulation of physiological processes, such as those of liver and vascular cells. This offers the potential to be used as artificial membranes or even organs such as the liver. However, this remains to be further researched [Sivanesan].
Bone Regeneration
Scaffolds created from Chitosan can be tailored to promote bone regeneration. Chitosan scaffolds can be customized to create optimal pore size, and surface to promote healing. Its use as a scaffold to encourage the formation of new extracellular matrix assists with cell proliferation and eventual bone regeneration [Tuzlakoglu,Ressler].
Nerve Regeneration
The physiological structure and properties of Chitosan also interact beneficially with nerve cells [Boecker,Liu]. This promotes cell differentiation and axonal regeneration by providing structural and biochemical support to their healing process. Furthermore, their capacity to carry and deliver growth factors locally can further promote growth and recovery.
Cartilage Regeneration
Despite traditionally poor healing of cartilage due to suboptimal blood supply, Chitosan is also effective at stimulating intra-articular cartilage regeneration. Its biocompatibility and biodegradability sufficiently stimulate the local environment to promote connective tissue and vascular growth to assist natural repair [Li,Ravanetti].
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