Gene Delivery
Mykito Chitosan is the purest Non-Animal chitosan in the world. This chitosan does not have the betaglucins, heavy metals and other contaminants that are commonly found in chitosan. The Mykito technology is robust, repeatable and produces consistent results.
Nanoparticle Formulations
Chitosan can be produced as nanoparticles to condense and carry genetic material like DNA plasmids and RNA for gene therapy. As genetic materials are easily degraded in bodily tissues, effective transfection vectors are required for effective delivery. Chitosan nanoparticles safely deliver different forms of genetic materials into cells, where their positively charged surface can further enhance permeability and uptake/transfection rates [Bowman].
Stability
Genetic material is fragile and prone to degradation in most environments, and presents a significant challenge in the variability of gene therapy. The properties of Chitosan allow it to form stable complexes with genetic material to protect it from degradation and can help ensure high transfection rates [Strand,Cupino].
Sustained Release
The mechanical properties of Chitosan-based gene delivery systems can also provide a sustained release to ensure transfection rates and gene expression remain consistent over longer periods [Cao]. This provides more optimal effects compared to other carriers.
Reduced Toxicity
As chitosan is considered inert, it can overcome concerns regarding toxicity and immunogenicity concerns, especially when applied to tissues more prone to inflammatory damage [Cao].
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