Orthopedic Implants and Devices
Mykito Chitosan is the purest Non-Animal chitosan in the world. This chitosan does not have the betaglucins, heavy metals and other contaminants that are commonly found in chitosan. The Mykito technology is robust, repeatable and produces consistent results.
Implant and coating
Chitosan-based materials are both biologically inert, but can also be moulded into different structures. For example, it may be used to create porous structures that facilitate cell growth in and over the implant osteo-conduction [Di Martino].
Drug Delivery
Chitosan can act as an effective drug delivery system and synergize with drugs while providing additional biocompatibility when incorporated into orthopedic implants. Chitosan layers can be produced by the dip-coating technique and used to encapsulate drugs like antibiotics. This achieves steady release into the post-operative wound environment to target common pathogens, promoting bone healing, preventing infections, and reducing inflammation [Soares].
Coating Material
Chitosan coatings can be applied to orthopedic implants, such as screws, plates, or prosthetic joints to combat the formation of bacterial biofilms. This can be achieved by modifying the implant surface with Chitosan [Gassman]. These coatings may enhance the biocompatibility of the implant, reduce wear and friction, and improve osseointegration (the bonding of the implant to the surrounding bone).
Antibacterial Properties
The natural antibacterial properties of Chitosan, can also be used to reduce postoperative infection rates. This can be achieved by incorporating its molecules or nanofibers in or over implants to exert its antimicrobial actions [Boschetto].
Bone Regeneration
Scaffolds created from Chitosan can be tailored to promote bone regeneration. Chitosan scaffolds can be customized to create optimal pore size, and surface to promote healing. Its use as a scaffold to encourage the formation of new extracellular matrix assists with cell proliferation and eventual bone regeneration [Tuzlakoglu,Ressler].
Nerve Regeneration
The physiological structure and properties of Chitosan also interact beneficially with nerve cells [Boecker,Liu]. This promotes cell differentiation and axonal regeneration by providing structural and biochemical support to their healing process. Furthermore, their capacity to carry and deliver growth factors locally can further promote growth and recovery.
Cartilage Regeneration
Despite traditionally poor healing of cartilage due to suboptimal blood supply, Chitosan is also effective at stimulating intra-articular cartilage regeneration. Its biocompatibility and biodegradability sufficiently stimulate the local environment to promote connective tissue and vascular growth to assist natural repair [Li,Ravanetti].
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