Biomedical Scaffolds
Mykito Chitosan is the purest Non-Animal chitosan in the world. This chitosan does not have the betaglucins, heavy metals and other contaminants that are commonly found in chitosan. The Mykito technology is robust, repeatable and produces consistent results.
Dental Implant Scaffolds
The surface of dental implants may be modified using Chitosan to increase the rate of healing and osseointegration [Alnufaiy]. The surface modification can be achieved by laser-treating the implant before coating it with Chitosan. This promotes biomineralization and osteoblast formation by providing biocomposite scaffolds.
Bone Regeneration
Chitosan scaffolds can be customized to create optimal pore size, and surface to promote healing. Its use as a scaffold to encourage the formation of new extracellular matrix assists with cell proliferation and eventual bone regeneration [Tuzlakoglu,Ressler]. This can be applied to dental implants to assist dental pulp regeneration as well [Moreira, Levengood].
Cardiac Scaffold
Chitosan can be used to create cardiac extracellular matrix scaffolds to repair congenital defects [Lv]. These implants can integrate well into the body tissue and the porous scaffold structure effectively facilitates cell survival and proliferation. Chitosan implants can also improve recovery by limiting scarring and promoting blood vessel development following heart attacks [Wang]. Valves can also be coated in Chitosan to enhance their regenerative potential [Jahnavi].
Stem cell and gene therapy
After traumatic events such as heart attacks, the heart can be significantly impaired and can potentially be addressed with Chitosan. Chitosan-based scaffolds and nanofibers can provide an effective platform for cardiac stem cells, or injected stem cells, to grow and spread [Patel]. Stem cells are cells that can differentiate into other types of cells, such as heart cells. By delivering stem cells to the heart, it is possible to repair damaged heart tissue. Chitosan nanofibers and scaffolds can also stimulate the genes involved in cardiac contraction and coupling to facilitate electrical conduction [Martins].
Tissue Engineering
The addition of Chitosan onto existing 3D scaffolds, or purely Chitosan-based hydrogels, offers an effective surface to improve compatibility with blood and cells [Wang]. Chitosan’s plasticity allows it to be molded, printed, coated, and electro-spunned into different 3D structures/forms to accommodate different cell types and functions/tissues.
Transplant Applications
The effects of Chitosan structures also extend to the modulation of physiological processes, such as those of liver and vascular cells. This offers the potential to be used as artificial membranes or even organs such as the liver. However, this remains to be further researched [Sivanesan].
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