Drug Delivery Systems
Mykito Chitosan is the purest Non-Animal chitosan in the world. This chitosan does not have the betaglucins, heavy metals and other contaminants that are commonly found in chitosan. The Mykito technology is robust, repeatable and produces consistent results.
Orthopedic implants
Chitosan can act as an effective drug delivery system and synergize with drugs while providing additional biocompatibility when incorporated into orthopedic implants. Chitosan layers can be produced by the dip-coating technique and used to encapsulate drugs like antibiotics. This achieves steady release into the post-operative wound environment to target common pathogens, promoting bone healing, preventing infections, and reducing inflammation [Soares].
Dental implants
Chitosan’s mucoadhesive and enhanced penetration properties make Chitosan a suitable drug delivery system. Dental implants with Chitosan may be used to incorporate bone morphogenetic proteins and various growth factors to induce and promote bone formation peri-operatively [Aguilar].
Cardiac implants
The physical and chemical properties of Chitosan make it an excellent carrier of biomolecules to assist in the repair and regeneration of the heart. Its positive charge and hydrophilicity allow a suitable microenvironment to carry and synergize with biomolecules [Patel].
Drug delivery vector
Chitosan nanoparticles can also effectively encapsulate and deliver drugs in the form of microparticles, nanoparticles, and hydrogels. This can be incorporated into the delivery of common and specialized treatments across various body systems. Chitosan can be customized to provide sustained, controlled, and site-specific release of drugs [Garg,Su]. This can be applied across various bodily tissues, including the delivery to ocular, oral, nasal and genitourinary systems.
Gastrointestinal/Oral Drug Delivery
One of the main challenges in drug development is ensuring adequate gastrointestinal absorption, and Chitosan can be utilized as a coating or binding material for tablets, capsules, and granules to overcome the hazardous environment of the gut. Through various physical and chemical modifications to Chitosan, this can tailor its protection against degradation by low gastric pH, enzymes, and mucus, ensuring sufficient delivery to its intended sites [Pathomthongtaweechai].
Nasal Drug Delivery
Chitosan can also be utilized in nasal drug delivery to safely overcome the quick mucociliary clearance. By administering it as a micro- or nano-particle, its mucoadhesive properties can be used to allow a more prolonged drug absorption and action profile. It has been shown to provide an effective and lasting effect on conditions like rhinitis and COVID-19 [Wang,Pyrc].
Drug Delivery
Hydrogels produced from Chitosan also make excellent drug delivery systems. By acting as high-capacity reservoirs with good adhesion to local tissues, sustained drug release can be achieved to optimize the biochemical and physiological environment for healing [Freedman].
Drug Delivery
Chitosan-based micro- and nano-carriers can also be applied to animals to assist with safe, effective, and targeted delivery of medication. This can be used in the delivery of enteral and mucosal medications or vaccines to ensure the drugs reach the right location for a stable absorption profile. This relies on its structure for chemical and mechanical protection, mucoadhesive properties to ensure prolonged absorption, and immunological influences to promote effective response [Senel,Drewnowska,Maldonado-Cabrera].
Nanoparticle Formulations
Chitosan can be produced as nanoparticles to condense and carry genetic material like DNA plasmids and RNA for gene therapy. As genetic materials are easily degraded in bodily tissues, effective transfection vectors are required for effective delivery. Chitosan nanoparticles safely deliver different forms of genetic materials into cells, where their positively charged surface can further enhance permeability and uptake/transfection rates [Bowman].
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